Guidance Document Information (PDF)

Guidance Document Portal

Administering and Dispensing

Buprenorphine (MOUD)

Civil Unrest/Looting Registration Guidance Documents

Controlled Substances


CSOS (Controlled Substances Ordering System)

DEA Form 222 (Order Forms)

Disposal and/or Destruction

Double-Blind Study

Electronic Prescriptions for Controlled Substances (EPCS)

Employment Waivers


Listed Chemicals

Marihuana Growers

Opioid Use Disorder – MATE Act

Narcotic Treatment Programs (NTP)




Reverse Distributors

Suspicious Orders (SORS)

Theft or Loss

Disclaimer: Guidance documents, like this document, are not binding and lack the force and effect of law, unless expressly authorized by statute or expressly incorporated into a contract, grant, or cooperative agreement. Consistent with Executive Order 13891 and the Office of Management and Budget implementing memoranda, the Department will not cite, use, or rely on any guidance document that is not accessible through the Department's guidance portal, or similar guidance portals for other Executive Branch departments and agencies, except to establish historical facts. To the extent any guidance document sets out voluntary standards (e.g., recommended practices), compliance with those standards is voluntary, and noncompliance will not result in enforcement action. Guidance documents may be rescinded or modified in the Department's complete discretion, consistent with applicable laws.