It is DEA’s goal to maintain a positive working relationship with all of its registrants, including researchers. DEA and researchers have a common interest in the appropriate use of controlled substances. An effective working relationship to ensure compliance with federal requirements will continue to produce lasting benefits on a national scale.

Researcher’s Manual (Revised 2022)

Before You Apply: Checklist of Required Materials

Controlled Substance Code Number



New Applications

Form 225, to establish a registration.

Renewal Applications

Form 225a, to renew an existing registration.

Make Changes to My DEA Registration

Make changes to an existing registration (e.g., update name or address, amend an already approved protocol, add a supplemental protocol, add drug codes, change drug quantities, etc.)

Check the Status of My Registration

Has my registration been processed yet?

Request Copy of DEA Certificate

Duplicate Certificates for misplaced, illegible, or destroyed originals.


Related DEA Forms

Order Form Request

Request Official Order Forms (Schedule I & II Registrants Only)

Registrant Record of Controlled Substances Destroyed

Form 41

TLR (Theft/Loss Reporting Online)

Formerly DTL (Drug/Theft Loss)

DEA Form 106 – Report of Theft or Loss of Controlled Substances (and disposal receptacles)


Registration Resources

Registrant Population (Active)


Registration Support

Call DEA Registration Service Center at 1-800-882-9539 (8:30 am-5:50 pm ET).

Contact scientific staff for help with your schedule I controlled substances research application. Email: – please include your DEA registration/application number in your email.

Locate your local Field Office to speak to a Diversion Investigator or Registration Specialist.